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KB03002 | LPO Assay Kit | Lipid Peroxidation (MDA + HNE)

189.00454.00 TAX excl.

LPO assay kit measures MDA and HNE concentrations as an index of lipid peroxidation. Firstly, an acid-catalyzed attack at the 3-position of the indole ring initiates the reactions between indoles and aldehydes (MDA and HNE). As a result, this reaction gives a diindolylalkane (chromophore) with maximum absorbance in the region of 580-620 nm.

Malondialdehyde (MDA) and 4-Hydroxynonenal (4-HNE) are important toxic byproducts of lipid peroxidation. So, the measurement of the amounts of such aldehydes corresponds to an index of lipid peroxidation in vitro and in vivo. 4-HNE is a major product of the peroxidative decomposition of ω-6 polyunsaturated fatty acids (PUFA). It possesses cytotoxic, hepatotoxic, mutagenic, and genotoxic properties. Furthermore, increased levels of HNE were found in plasma and various organs under oxidative stress conditions. In fact, MDA is in many instances the most abundant individual aldehyde resulting from lipid peroxidation. In vitro, MDA can alter proteins, DNA, RNA, and many other biomolecules.

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Additional information

Test

100, 200, 400

Publications

  • Ahmed, Marwa A., and Esam O. Kamel. 2020. “Involvement of H2S, NO and BDNF‐TrkB Signalling Pathway in the Protective Effects of Simvastatin against Pentylenetetrazole‐induced Kindling and Cognitive Impairments in Mice.” Basic & Clinical Pharmacology & Toxicology, July, bcpt.13457. https://doi.org/10.1111/bcpt.13457.
  • Gila-Díaz, Andrea, Gloria Herranz Carrillo, Silvia Cañas, Miguel Saenz de Pipaón, José Antonio Martínez-Orgado, Pilar Rodríguez-Rodríguez, Ángel Luis López de Pablo, María A. Martin-Cabrejas, David Ramiro-Cortijo, and Silvia M. Arribas. 2020. “Influence of Maternal Age and Gestational Age on Breast Milk Antioxidants during the First Month of Lactation.” Nutrients 12 (9): 1–14. https://doi.org/10.3390/nu12092569.
  • Flores‑Fernandez, Jose, Eduardo Padilla‑Camberos, Ofelia Fernandez‑Flores, Nestor Diaz‑Martinez, Carla Barragan‑Alvarez, and Patricia Ramirez‑Rodriguez. 2019. “Gastroprotective Activity and Pharmacological Safety Evaluation of Eupatorium Aschenbornianum.” Experimental and Therapeutic Medicine 18 (October): 4467–72. https://doi.org/10.3892/etm.2019.8093.
  • Reyes-Hernández, Cynthia Guadalupe, David Ramiro-Cortijo, Pilar Rodríguez-Rodríguez, Sonia Giambelluca, Manuela Simonato, Ma Del Carmen González, Angel Luis López de Pablo, et al. 2018. “Effects of Arachidonic and Docosohexahenoic Acid Supplementation during Gestation in Rats. Implication of Placental Oxidative Stress.” International Journal of Molecular Sciences 19 (12). https://doi.org/10.3390/ijms19123863
  • Reyes-Hernández, Cynthia Guadalupe, David Ramiro-Cortijo, Pilar Rodríguez-Rodríguez, Sonia Giambelluca, Manuela Simonato, Ma Del Carmen González, Angel Luis López de Pablo, et al. 2018. “Effects of Arachidonic and Docosohexahenoic Acid Supplementation during Gestation in Rats. Implication of Placental Oxidative Stress.” International Journal of Molecular Sciences 19 (12). https://doi.org/10.3390/ijms19123863.
  • Gila-Díaz, A., Herranz Carrillo, G., Cañas, S., Saenz de Pipaón, M., Martínez-Orgado, J. A., Rodríguez-Rodríguez, P., … Arribas, S. M. (2020). Influence of Maternal Age and Gestational Age on Breast Milk Antioxidants During the First Month of Lactation. Nutrients, 12(9), 2569
  • Sex Differences in Placental Protein Expression and Efficiency in a Rat Model of Fetal Programming Induced by Maternal Undernutrition
  • Ahmed, M. A., & Kamel, E. O. (2020). Involvement of H 2 S, NO and BDNF‐TrkB signalling pathway in the protective effects of simvastatin against pentylenetetrazole‐induced kindling and cognitive impairments. Basic & Clinical Pharmacology & Toxicology.

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